Sunday, January 26, 2014

WHAT IS RENAL TOXIC? Let's start with NSAIDS.

Let's start with prostaglandin inhibitors. What is that you say? The most commonly available are the nonsteroidal antiinflammatory (NSAID) medications that you can buy anywhere, they go by different names: motrin, ibuprofen, aleve, naproxen, aspirin. The last one we try to avoid because of Reyes syndrome. The problem is that there are certain genes were are born with, one of which is the COX (cyclooxygenase)-2 gene that is responsible for the growth of certain parts of our kidneys the tubule and glomeruli. Maybe it isn't so important once your kidneys have grown, but before that it may be. So if you take a medicine that inhibits those functions early on, too frequently, that can be a problem. The National Institutes of Health (NIH) recommend all people with impaired renal function (hypertension, congestive heart failure, kidney failure, or in general over the age of 60) avoid all of the NSAIDS because of that risk to the kidneys.

Also dehydration, heat stroke, hepatic failure.

If you look at the precautions written on the backside of an ibuprofen label, you will see a partial list of what I am talking about. So, I recommend Ice and Heat for pain instead of medications, and topical ointments like aspercreme (no methol or capescein so it won't sting), side effects: none, and can be used over and over again, no build up.


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